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DEAD-box RNA Helicases
Concept
Why?
Staley, Jonathan P.
Person
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A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity.
Academic Article
Why?
Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-a and serologic autoimmunity in lupus patients.
Academic Article
Why?
Conventional protein kinase C-a (PKC-a) and PKC-ß negatively regulate RIG-I antiviral signal transduction.
Academic Article
Why?
Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.
Academic Article
Why?
DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-?B and sensitize to alkylating chemotherapy.
Academic Article
Why?
DDX41-associated susceptibility to myeloid neoplasms.
Academic Article
Why?
DEAD on.
Academic Article
Why?
Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.
Academic Article
Why?
Dicer expression and microRNA dysregulation associate with aggressive features in thyroid cancer.
Academic Article
Why?
Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations.
Academic Article
Why?
Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences.
Academic Article
Why?
Germ line DDX41 mutations define a unique subtype of myeloid neoplasms.
Academic Article
Why?
Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.
Academic Article
Why?
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